Science Knows No Boundaries

Electroporation Knows No Boundaries

The discovery of RNA interference (RNAi) has enabled several breakthrough discoveries in the area of functional genomics. The RNAi technology has emerged as one of the major tools for drug target identification and has been steadily improved to allow gene manipulation in cell lines, tissues, and whole organisms. One of the major hurdles for the use of RNAi in high-throughput screening has been ...

Tae Hoon Kim: Knows his boundaries

JCB • VOLUME 183 • NUMBER 1 • 2008 4 W hen and where a gene is expressed depends on its associated regulatory elements, chromatin environment, transcription factors, and numerous other infl uences that scientists do not yet fully understand. Because each gene has a particular expression pattern, it can be diffi cult to identify general rules for the switching on or off of genes. Tae Hoon Kim is...

Electroporation Knows No Boundaries: The Use of Electrostimulation for siRNA Delivery in Cells and Tissues.

The discovery of RNA interference (RNAi) has enabled several breakthrough discoveries in the area of functional genomics. The RNAi technology has emerged as one of the major tools for drug target identification and has been steadily improved to allow gene manipulation in cell lines, tissues, and whole organisms. One of the major hurdles for the use of RNAi in high-throughput screening has been ...

No body knows the trouble I've seen.

Toward Clarity on Whole Science and KNOWS

I am pleased to have an opportunity to clarify my proposals for teaching Whole Science and assessing knowledge of the nature of science through seeking a well-informed analysis of case studies in the news (Allchin, 2011; assumed in page references below). In this, I echoed similar earlier proposals by Norris and Phillips (1994), Glynn and Muth (1994), Korpan, Bisanz, Bisanz and Henderson (1997)...